Download Proton TP-4207 Hard Reset File

Download Proton TP-4207 factory reset file

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9. The composition of claim 1, wherein the compound is of the Formula Ip: or a pharmaceutically acceptable salt thereof.

12. The composition of claim 1, wherein the compound is of the Formula Is: or a pharmaceutically acceptable salt thereof.

16. The composition of claim 1, wherein the compound is of the Formula Iw: or a pharmaceutically acceptable salt thereof.

In another specific embodiment, a compound disclosed herein, or a pharmaceutically acceptable salt thereof, is combined with an HBV DNA polymerase inhibitor, one or two additional therapeutic agents selected from the group consisting of immunomodulators, TLR modulators, HBsAg inhibitors, HBsAg secretion or assembly inhibitors, HBV therapeutic vaccines, HBV antibodies including HBV antibodies targeting the surface antigens of the hepatitis B virus and bispecific antibodies and “antibody-like” therapeutic proteins (such as DARTs®, DUOBODIES®, BITES®, XmAbs®, TandAbs®, Fab derivatives, or TCR-like antibodies), cyclophilin inhibitors, stimulators of retinoic acid-inducible gene 1, stimulators of RIG-I like receptors, PD-1 inhibitors, PD-L1 inhibitors, Arginase inhibitors, PI3K inhibitors, IDO inhibitors, and stimulators of NOD2, and one or two additional therapeutic agents selected from the group consisting of HBV viral entry inhibitors, NTCP inhibitors, HBx inhibitors, cccDNA inhibitors, HBV antibodies targeting the surface antigens of the hepatitis B virus, siRNA, miRNA gene therapy agents, sshRNAs, KDM5 inhibitors, and nucleoprotein modulators (HBV core or capsid protein modulators).

In certain embodiments of Formula (I), R 1 is —H or C1-4 alkyl; R 2 is C3-6 alkyl; Q is CR 4 ; R 3 and R 4 are taken together to form C5-6 cycloalkyl; 5 to 6 membered heterocyclyl having 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur; phenyl; or 5 to 6 membered heteroaryl having 1 to 3 heteroatoms selected from oxygen, nitrogen, and sulfur, wherein: phenyl is optionally substituted with 1 to 3 halogen; 5 to 6 membered heteroaryl is optionally substituted with 1 to 3 R 6 ; each R 6 is independently halogen, —OH, C1-4 alkyl, or C1-4 alkoxy; and 5 to 6 membered heterocyclyl is optionally substituted with 1 to 3 —C(O)C1-4 alkyl.

In certain embodiments of Formula (I), (II), or (III), each R 5 is independently halogen, —OH, —NH2, —CN, C1-4 alkyl, C1-2 haloalkyl, C1-4 alkoxy, —C(O)OH, —C(O)C1-4 alkyl, —C(O)OC1-4 alkyl, —C(O)NH2, —C(O)NH(C1-4 alkyl), —C(O)N(C1-4 alkyl)2, —N(H)C(O)C1-4 alkyl, —S(O)2C1-4 alkyl. In certain embodiments of Formula (I), (II), or (III), each R 5 is independently chloro, fluoro, bromo, —CN, C1-2 alkyl optionally substituted with —OH, C1-2 alkoxy, —C(O)C1-2 alkyl, —C(O)OC1-2 alkyl, or pyrazolyl optionally substituted with 1 to 3 C1-2 alkyl; or imidazolyl optionally substituted with 1 to 3 C1-2 alkyl. In certain embodiments of Formula (I), (II), or (III), each R 5 is independently chloro, fluoro, bromo, —CN, —CH3, —CF3, —OCH3, —C(O)CH3, or —C(O)OCH3. In certain embodiments of Formula (I), (II), or (III), each R 5 is independently chloro, fluoro, bromo, —CN, —CH3, —OCH3, —C(O)CH3, or —C(O)OCH3.

Examples of PKC activators include indolactam, prostratin, ingenol B, and DAG-lactones.

anti-clusterin antibodies, such as AB-16B5;